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Nilotinib


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Product name:Nilotinib
CAS:641571-10-0
Molecular Formula:     C28H22F3N7O
Formula Weight:529.52
Description:
 Nilotinib, in the form of the hydrochloride monohydrate salt, is a tyrosine kinase inhibitor.
It inhibits BCR-ABL.
It was approved as Tasigna in the USA and the EU for drug-resistant chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib, also known by its clinical code AMN107, has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Glivec), another tyrosine kinase inhibitor currently used as a first-line treatment. In that study 92% of patients (already resistant or unresponsive to Glivec) achieved a normal white blood cell counts after five months of treatment. The drug carries a black box warning for possible heart complications.

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