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Introduction of Nafarelin acetate

  Nafarelin acetate is rapidly absorbed into system circulation after intranasal administration. T max is 10 to 40 min, C max is 0.6 to 1.8 ng/mL, and serum bioavailability is 2.8%.

  Nafarelin acetate is eliminated in urine (3% as unchanged) and feces. Serum t 1/ 2 is about 3 h (adults), 2.5 h (children), and 85.5 h (metabolites).

  SYNAREL (nafarelin acetate) Nasal Solution is advised for administering as a aerosol to the nasal mucosa. Nafarelin acetate, the alive basic of SYNAREL Nasal Solution, is a decapeptide with the actinic name: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-serylL-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide acetate. Nafarelin acetate is a syntheticanalog of the by itself occurring gonadotropin-releasing hormone (GnRH). Nafarelin acetate has the afterward actinic structure