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Nano drugs labeled "pass"


The body's immune system to recognize and destroy foreign matter. In addition to bacteria, viruses, drug delivery nanoparticles implanted pacemakers and artificial joints are also foreign objects, it will also trigger an immune reaction, leading to drug failure, rejection or inflammation. According to physicist organizational networks reported on February 21, the University of Pennsylvania scientists have developed a new method to treat these devices labeled protein "pass", so that they can go through the body's defense system. Related papers published in the recent "Science" (Science) magazine.


"The body of the invasion of foreign matter can be equally excluded." First author, University of Pennsylvania laboratory of molecular and cellular biophysics graduate student Pyle? Rodriguez said that this is the body's natural immune system caused. This process involves a variety of cells, such as macrophages can find, swallow and destroy the invaders; serum protein will stick on the target object, causing macrophages note that once macrophages was determined to stick foreign objects will swallow it, or send a signal to convene other macrophages surrounding it together.


To avoid nanoparticles trigger the innate immune response, the early approach is to give them a coat of polymer "brush coat", these "brushes" extending from nanoparticles to prevent all kinds of serum proteins on its surface sticky. But this can only postpone the moment but not a final settlement. Professor of Engineering and Applied Sciences, College of Chemistry and Biomolecular Engineering, University of Pennsylvania, Dennis? Disco and the research team another way: Let macrophage believe nanoparticles are "insiders" and let them.